The role of cavitation during shock wave exposure was poorly understood until now. Cavitational activity produces severe damage to nearby surfaces due to multiple high-speed liquid jets resulting from bubble collapse. These jet impacts can be made visible by microscopy. For investigating the presence of cavitational processes by shock waves outside and even inside of targets, we have performed the following experiments. Natural gallstones and artificial targets were examined microscopically with regard to the effects of shock pulses. Scanning electron and light microscopical investigations revealed regularly typical and uniform microjet impacts within the fissures and split lines. Since these experiments are the continuation of high-speed films of 10,000 frames/s of shock wave actions on targets, it is most likely that the shock wave produces at first split lines through the stone. Then liquid occupies these cracks. But the following shock waves create within these liquid-filled fissures cavitation and, therefore, cause the disintegration of the targets. It now becomes understandable why biliary lithotripsy is less effective than renal lithotripsy: bile fluid is a high-viscous liquid and, therefore, hinders the disintegration of stones more than low-viscous urine. Intervals between the application of shock waves in biliary lithotripsy therefore, should improve the treatment results.