DETERMINATION OF 1,4-BENZODIAZEPINES AND 1,5-BENZODIAZEPINES IN URINE USING A COMPUTERIZED GAS CHROMATOGRAPHIC-MASS SPECTROMETRIC TECHNIQUE

被引：47
|
作者：
MAURER, H [1 ]
PFLEGER, K [1 ]
机构：
[1] UNIV SAARLAND, INST PHARMAKOL & TOKIKOL, D-6650 HOMBURG, FED REP GER
来源：
JOURNAL OF CHROMATOGRAPHY | 1981年 / 222卷 / 03期
关键词：
D O I：
10.1016/S0378-4347(00)84141-9
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A clinical and forensic toxicological method for the determination of benzodiazepines and their main metabolites in human urine after acid hydrolysis is described. The extract is analyzed by computerized gas chromatography-mass spectrometry. An on-line computer allows rapid detection using mass fragmentography with the masses m/e 211, 230, 241, 244, 249, 262, 276 and 285. The mass fragmentogram and the underlying mass spectra of the hydrolysis products (benzophenones and analogs) are documented.
引用
收藏
页码：409 / 419
页数：11
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