STRUCTURE-ACTIVITY-RELATIONSHIPS OF SYNTHETIC METHYL GLYCYRRHETATE GLYCOSIDES

被引：7
|
作者：
TAKECHI, M
TANAKA, Y
机构：
[1] Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka
来源：
PHYTOCHEMISTRY | 1993年 / 32卷 / 05期
关键词：
STRUCTURE ACTIVITY RELATIONSHIPS; HEMOLYSIS; ANTIFUNGAL ACTIVITY; ANTIBACTERIAL ACTIVITY; SYNTHETIC GLYCOSIDES; GLYCYRRHETIC ACID; SAPONIN;
D O I：
10.1016/S0031-9422(00)95086-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Of 15 synthetic methyl glycyrrhetate glycosides, the monoglycosides having CH2OH-6 or Me-6 in their sugar moieties and the diglycosides having a (1-->4) linkage between the sugar residues showed higher haemolytic activities than the others. The beta-maltoside and beta-lactoside exhibited much stronger antifungal activities against Trichophyton mentagrophytes than the others. However, none of them exhibited antibacterial activity against Staphylococcus aureus or Bacillus subtilis.
引用
收藏
页码：1173 / 1175
页数：3
相关论文
共 50 条
  • [41] MECHANISMS OF TOXIC ACTION AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR ORGANOCHLORINE AND SYNTHETIC PYRETHROID INSECTICIDES
    COATS, JR
    ENVIRONMENTAL HEALTH PERSPECTIVES, 1990, 87 : 255 - 262
  • [42] STRUCTURE-ACTIVITY-RELATIONSHIPS OF SOME SYNTHETIC ATRIAL-NATRIURETIC-PEPTIDE ANALOGS
    CRAME, AJ
    DODDS, MG
    DOLAMORE, PG
    KITCHIN, J
    LOUTTIT, JB
    PIPE, AJ
    ROSS, BC
    SEALE, PW
    WARD, P
    WISE, H
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1990, 18 (06) : 1320 - 1321
  • [43] SYNTHETIC MODIFICATION OF A NOVEL MICROBIAL IONOPHORE - EXPLORATION OF ANTICOCCIDIAL STRUCTURE-ACTIVITY-RELATIONSHIPS
    GLAZER, EA
    KOSS, DA
    OLSON, JA
    RICKETTS, AP
    SCHAAF, TK
    WISCOUNT, RJ
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (10) : 1839 - 1844
  • [44] QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS AND CARMINATIVE ACTIVITY
    EVANS, BK
    JAMES, KC
    LUSCOMBE, DK
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (02) : 277 - 278
  • [45] STRUCTURE-ACTIVITY-RELATIONSHIPS IN STEROIDAL ANESTHETICS
    PHILLIPPS, GH
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1975, 6 (05): : 607 - 613
  • [46] STRUCTURE-ACTIVITY-RELATIONSHIPS AMONG ALKOXYPHENYLCYCLOALKYLPENICILLINS
    ORDUKHANYAN, AA
    LANDAU, MA
    RUDZIT, EA
    MNDZHOYAN, SL
    TERZAKHARYAN, YZ
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1980, 14 (02): : 65 - 70
  • [47] STRUCTURE-ACTIVITY-RELATIONSHIPS OF BUSPIRONE ANALOGS
    YEVICH, JP
    TEMPLE, DL
    NEW, JS
    TAYLOR, DP
    RIBLET, LA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1982, 183 (MAR): : 43 - MEDI
  • [48] STRUCTURE-ACTIVITY-RELATIONSHIPS OF RAPHANUSANINS AND THEIR ANALOGS
    SAKODA, M
    USUI, K
    ISHIZUKA, K
    HARADA, N
    ONO, H
    UDA, H
    HASEGAWA, K
    PHYTOCHEMISTRY, 1993, 32 (06) : 1371 - 1373
  • [49] STRUCTURE-ACTIVITY-RELATIONSHIPS OF DOPAMINE AGONISTS
    CANNON, JG
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1983, 23 : 103 - 130
  • [50] QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS FOR BIODEGRADATION
    PARSONS, JR
    GOVERS, HAJ
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 1990, 19 (02) : 212 - 227
12345