GANGLIOSIDE-DEPENDENT FACTOR, INHIBITING LIPID-PEROXIDATION IN RAT-BRAIN SYNAPTOSOMES

被引：31
|
作者：
TYURIN, VA
TYURINA, YY
AVROVA, NF
机构：
[1] Institute of Evolutionary Physiology, Biochemistry Academy of Science, U.S.S.R., Leningrad
来源：
NEUROCHEMISTRY INTERNATIONAL | 1992年 / 20卷 / 03期
关键词：
D O I：
10.1016/0197-0186(92)90055-V
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Preincubation of rat brain synaptosomes with GM1, GD1a or GT1b (10(-10)-10(-6) M), as well as with phorbol 12-myristate, 13-acetate (10(-10)-10(-6) M) was found to have dose dependent inhibitory effect on Fe2+-ascorbate induced lipid peroxidation, while penetrating analogue of c-AMP markedly decreased the inhibitory effect of these compounds. In liposomes made of lipids isolated from synaptosomal membranes the degree of inhibition of induced LPO by gangliosides was practically absent. The inhibitory effect of GM1 on lipid peroxidation could not be revealed after thermal denaturation of synaptosomes or after treatment with polymyxin B (inhibitor of lipid-dependent protein kinases). These results and some other data provide evidence for the existence of ganglioside-dependent factor inhibiting lipid peroxidation in brain tissue. It may be suggested to be a protein kinase modulated by gangliosides.
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页码：401 / 407
页数：7
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