Synthesis and biological studies of 1, 2, 3, 4-tetrahydro pyrimidine derivatives

被引：0

作者：

Chaudhari, Parthiv K. ^{[1
]}

Pandey, Ajay ^{[1
]}

Shah, V. H. ^{[1
]}

机构：

[1] KSKV Kachchh Univ, Dept Chem, Bhuj Kachchh, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2010年 / 26卷 / 04期

关键词：

Dihydropyrimidines; Antitubercular activity; Antimycobacterial activity;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been found that several DHPM derivatives possess biological activity, which has led to their use as antiviral, antibiotic, anticarcinogenic, antihypertensive, antitubericular, anti mycobacterial or anticancer activity. Further more, DHPM s are chiral compounds and it has been discovered that the configuration at the steriogenic carbon C4 determines their biological properties. DHPMs Derivatives are synthesized via a multicomponent reaction of aldehyde derivative, urea or thiourea and 1,3-dicarbonyl compounds using Biginelli Reaction and microwave irradiation catalyzed by HCl. 1H NMR, IR, mass spectra and CHN analysis data established identification of the compounds are evaluated for their antiviral, antibiotic, anticarcinogenic, antihypertensive, antitubericular, anti mycobacterial or anticancer activity.

引用

页码：1377 / 1383

页数：7

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