THE EFFECTS OF BENZAMIL ON IN-VITRO CONTRACTURE RESPONSES OF HUMAN SKELETAL-MUSCLE TO HALOTHANE

被引：1
|
作者：
HOPKINS, PM
ELLIS, FR
HALSALL, PJ
机构：
来源：
GENERAL PHARMACOLOGY | 1994年 / 25卷 / 01期
关键词：
SKELETAL MUSCLE; MALIGNANT HYPERTHERMIA; HALOTHANE; BENZAMIL; SODIUM-CALCIUM EXCHANGE;
D O I：
10.1016/0306-3623(94)90006-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Inhibition of sodium-calcium exchange using 100 mu M benzamil caused contracture development of in vitro skeletal muscle samples from humans susceptible to malignant hyperthermia, but not of samples from normal individuals. 2. This dose of benzamil increased the contracture response of both types of muscle to halothane. 3. At a concentration of 1 mu M, benzamil significantly reduced the contracture response to halothane of muscle from malignant hyperthermia individuals. 4. The implications for the role of sodium-calcium exchange in skeletal muscle calcium homeostasis and the pathophysiology of malignant hyperthermia are discussed.
引用
收藏
页码：23 / 29
页数：7
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