COLLAGEN BASED BIOMATERIALS - AN IDEAL WAY OF INCREASING THEIR RESISTANCE TO INFECTION

被引：5

作者：

GUNASEKARAN, S

CHVAPIL, M

机构：

[1] Department of Surgery, Arizona Health Sciences Center, University of Arizona, Tucson, AZ 85724, United States

来源：

BIOMATERIALS ARTIFICIAL CELLS AND ARTIFICIAL ORGANS | 1988年 / 16卷 / 04期

关键词：

Collagen; -; Gels;

D O I：

10.3109/10731198809117568

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Resorcinol monoacetate (RMA) is a relatively water insoluble antibacterial agent which partially crosslinks collagen and has the potential to be an intrinsic antibiotic in collagenous bioprostheses. This study confirms the efficacy of RMA as a chemical that: (a) mildly crosslinks collagen at pH 3.5-4.5; (b) releases very slowly from the pretreated collagen sponge when washed in aqueous medium; (c) inhibits bacterial growth on the pretreated collagen sponges, at 2% (w/w) concentration, for at least 12 days; (d) remains biocompatible under treated conditions.

引用

页码：771 / 784

页数：14

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