AGE-DIFFERENCES IN RESPONSIVENESS OF BRAIN-STEM CHEMOSENSITIVE NEURONS TO EXTRACELLULAR PH CHANGES

被引:4
|
作者
WHITTAKER, JAC
TROUTH, CO
PAN, Y
MILLIS, RM
BERNARD, DG
机构
[1] Department of Physiology and Biophysics, College of Medicine, Howard University, Washington
关键词
D O I
10.1016/0024-3205(90)90385-5
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The sensitivity of neurons in the caudal chemosensitive area on the ventrolateral surface of the medulla oblongata (VMS) to extracellular pH changes was examined in newborn and young developing kittens and compared to that of adult cats. The pH was varied by superfusion of the VMS with mock cerebrospinal fluid (CSF) of pH 7.4 (control), 7.0 (acid) and 7.8 (alkaline). A total of 97 neuronal units in the three age groups changed their firing rates inversely in response to extracellular fluid (ECF) pH changes. The greatest sensitivity was found in the adult group where acid superfusion caused an increase in neuronal activity. The least sensitivity was observed in the newborn group (1-6 days old), whereas the young kitten group (4-6 weeks old) exhibited an intermediate sensitivity. Neurons of kittens older than 7 weeks of age demonstrated a response pattern characteristic of the adult group. Neurons of neonates older than seven days, exhibited a response pattern characteristic of the young kitten group. © 1990.
引用
收藏
页码:1699 / 1705
页数:7
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