GAMMA-PYRONE COMPOUNDS AS POTENTIAL ANTICANCER DRUGS

被引：53
|
作者：
LIOU, SS
SHIEH, WL
CHENG, TH
WON, SJ
LIN, CN
机构：
[1] KAOHSIUNG MED COLL, NAT PROD RES CTR, KAOHSIUNG 807, TAIWAN
[2] CHIA NAN JUNIOR COLL PHARM, DEPT PHARM, TAINAN 717, TAIWAN
[3] NATL CHENG KUNG UNIV, COLL MED, DEPT MICROBIOL, TAINAN 701, TAIWAN
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 09期
关键词：
D O I：
10.1111/j.2042-7158.1993.tb05686.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The gamma-pyrones, artomunoxanthotrione epoxide, cyclocommunol, cyclomulberrin, and cyclocommunin exhibited potent inhibition of human PLC/PRF/5 and KB cells in-vitro. Dihydroisocycloartomunin showed significant and potent inhibition of human PLC/PRF/5 and KB cells in-vitro, respectively. Cyclomorusin, dihydrocycloartomunin and artomunoxanthone showed significant inhibition of KB cells in-vitro. Based on the above finding and the reported antileukaemic activity of xanthone psorospermin, a series of natural gamma-pyrones was prepared and the inhibition of human PLC/PRF/5 and KB cells in-vitro was measured. Structure-activity analysis indicated the epoxide group substituted at 3-hydroxyl and 2,6-; 3,6-; and 3,5-dihydroxyl xanthone enhanced the anti-tumour activity. The epoxide group substituted at the 6-hydroxyl group of 1,6-dihydroxyxanthone did not show anti-tumour activity.
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页码：791 / 794
页数：4
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