IMMUNOHISTOCHEMICAL EVALUATION OF BONE-MARROW LYMPHOID NODULES IN CHRONIC MYELOPROLIFERATIVE DISORDERS

被引：16
|
作者：
FRANCO, V [1 ]
FLORENA, AM [1 ]
ARAGONA, F [1 ]
CAMPESI, G [1 ]
机构：
[1] UNIV PALERMO,IST ANAT PATOL,POLICLIN VIA VESPRO 129,I-90129 PALERMO,ITALY
来源：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1991年 / 419卷 / 04期
关键词：
LYMPHOID NODULES; CHRONIC MYELOPROLIFERATIVE DISORDERS; BONE MARROW; IMMUNOHISTOCHEMISTRY;
D O I：
10.1007/BF01606516
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
One hundred and seventy bone marrow biopsies from patients with chronic myeloproliferative disorders (CMPDs) were evaluated for the presence of lymphoid nodules (LNs) and were immunostained using a panel of monoclonal antibodies (UCHL1, 4KB5 and L26) recognizing different lymphocyte antigens. LNs were found in 35% of cases of idiopathic thrombocythaemia, 24.6% of myelofibrosis/osteomyelosclerosis, 18.2% of polycythaemia vera, 12.1% of chronic myeloid leukaemia and 19.2% of borderline cases. Varying degrees of immunohistochemical positivity for the three antibodies tested were found. LNs were always made up of variable proportions of both T- and B-lymphocytes with a prevalence of T-cells. This latter observation suggests that bone marrow LNs in CMPDs could be an expression of reactivity.
引用
收藏
页码：261 / 266
页数：6
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