IMMUNOHISTOCHEMICAL EVALUATION OF BONE-MARROW LYMPHOID NODULES IN CHRONIC MYELOPROLIFERATIVE DISORDERS

被引：16

作者：

FRANCO, V ^{[1
]}

FLORENA, AM ^{[1
]}

ARAGONA, F ^{[1
]}

CAMPESI, G ^{[1
]}

机构：

[1] UNIV PALERMO,IST ANAT PATOL,POLICLIN VIA VESPRO 129,I-90129 PALERMO,ITALY

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1991年 / 419卷 / 04期

关键词：

LYMPHOID NODULES; CHRONIC MYELOPROLIFERATIVE DISORDERS; BONE MARROW; IMMUNOHISTOCHEMISTRY;

D O I：

10.1007/BF01606516

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

One hundred and seventy bone marrow biopsies from patients with chronic myeloproliferative disorders (CMPDs) were evaluated for the presence of lymphoid nodules (LNs) and were immunostained using a panel of monoclonal antibodies (UCHL1, 4KB5 and L26) recognizing different lymphocyte antigens. LNs were found in 35% of cases of idiopathic thrombocythaemia, 24.6% of myelofibrosis/osteomyelosclerosis, 18.2% of polycythaemia vera, 12.1% of chronic myeloid leukaemia and 19.2% of borderline cases. Varying degrees of immunohistochemical positivity for the three antibodies tested were found. LNs were always made up of variable proportions of both T- and B-lymphocytes with a prevalence of T-cells. This latter observation suggests that bone marrow LNs in CMPDs could be an expression of reactivity.

引用

页码：261 / 266

页数：6

共 50 条

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