Common Carotid Arteries Occlusion Surgery in Adult Rats as a Model of Chronic Cerebral Hypoperfusion

被引：14
|
作者：
Cao, Dandan [1 ]
Bai, Yunfei [1 ]
Li, Liang [1 ]
机构：
[1] CapitalMed Univ, Dept Pathol, Sch BasicMed Sci, 10 Xi Tou Tiao,You An Men St, Beijing, Peoples R China
来源：
BIO-PROTOCOL | 2018年 / 8卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Chronic cerebral hypoperfusion; Vascular dementia; Alzheimer's disease; Two-vessel occlusion; Cerebral blood flow; White matter;
D O I：
10.21769/BioProtoc.2704
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Chronic cerebral hypoperfusion (CCH) is an important risk factor of vascular dementia (VaD) and Alzheimer's disease (AD). Hypoxia/ischemia in the whole brain induced by CCH causes serious damage to brain structure and function, which can lead to cognitive impairment. Two-vessel occlusion (2-VO), also known as permanent, bilateral common carotid artery occlusion, is one of the most widely used animal models (e.g., rat) of CCH to investigate the mechanisms of neurodegenerative processes. In this protocol, we present the surgical procedure for 2-VO in rats.
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页数：10
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