2'-DEOXY-BETA-L-PENTOFURANOSYL AND/OR 3'-DEOXY-BETA-L-PENTOFURANOSYL NUCLEOSIDE DERIVATIVES - STEREOSPECIFIC SYNTHESIS AND ANTIVIRAL ACTIVITIES

被引：23
|
作者：
GOSSELIN, G
MATHE, C
BERGOGNE, MC
AUBERTIN, AM
KIRN, A
SOMMADOSSI, JP
SCHINAZI, R
IMBACH, JL
机构：
[1] UNIV STRASBOURG 1,INSERM,U74,F-67000 STRASBOURG,FRANCE
[2] UNIV ALABAMA,DEPT PHARMACOL,BIRMINGHAM,AL 35294
[3] VET AFFAIRS MED CTR,DECATUR,GA 30033
来源：
NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期
关键词：
D O I：
10.1080/15257779508012437
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several L-enantiomers of nucleoside analogues were stereospecifically synthesized by a multi-step reaction from L-xylose and their antiviral properties were examined in vitro. Two of them, namely beta-L-2',3,-dideoxycytidine (beta-L-ddC) and its 5-fluoro derivative (beta-L-FddC) were found to have potent anti-human immunodeficiency virus (HIV) and significant antihepatitis B virus (HBV) activities in cell cultures.
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页码：611 / 617
页数：7
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