TETRAZOLE COMPOUNDS .8. SYNTHESIS OF TETRAZOLYLPYRIMIDINES FROM TETRAZOLYL-SUBSTITUTED ENAMINO KETONES

Tetrazolyl-substituted enamino ketones 1 react with various amidines 2 to give 5-(1-phenyl-1H-tetrazol-5-yl)pyrimidines & In the case of the chloroacetyl enamine 4 4-(N,N-dimethylaminomethyl)-substituted tetrazolylpyrimidines 5 were obtained. Subsequent hydrolysis of the 4-trifluoromethyl derivatives 3b, 3d and 3g afforded the corresponding 5-(1-phenyl-1H-tetrazol-5-yl)pyrimidine-4-carboxylic acids 6.