BETA(2)-MICROGLOBULIN-INDEPENDENT MHC CLASS IB MOLECULE EXPRESSED BY HUMAN INTESTINAL EPITHELIUM

被引：146

作者：

BALK, SP

BURKE, S

POLISCHUK, JE

FRANTZ, ME

YANG, L

PORCELLI, S

COLGAN, SP

BLUMBERG, RS

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV GASTROENTEROL,BOSTON,MA 02115

[2] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV HEMATOL ONCOL,BOSTON,MA 02215

[3] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT RHEUMATOL IMMUNOL,LYMPHOCYTE BIOL SECT,BOSTON,MA 02115

[4] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT ANESTHESIA,BOSTON,MA 02115

来源：

SCIENCE | 1994年 / 265卷 / 5169期

关键词：

D O I：

10.1126/science.7517575

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A major histocompatibility complex class Ib protein, CD1d, is expressed by human intestinal epithelial cells (IECs) and is a ligand for CD8(+) T cells. CD1d was found to be expressed on the surface of human IECs as a 37-kilodalton protein that was beta(2)-microglobulin (beta(2)M) independent with no N-linked carbohydrate. Transfection into a beta(2)M(-) cell line confirmed that CD1d could be expressed at the cell surface in the absence of beta(2)M. These data indicate that IECs use a specialized pathway for CD1d synthesis and that a beta(2)M-independent class Ib protein may be the normal ligand for some intestinal T cells.

引用

页码：259 / 262

页数：4

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