Evaluation of Mangifera indica leaves for its Anti Obesity Activity in Rats.

The present study was undertaken to evaluate anti-obesity effect of Ethanolic extract of Mangifera indica leaves on rats fed on HFD (High Fat Diet) along with exercise. The study was conducted for 40 days. High Fat Diet was used to induce obesity. Along with the induction of obesity, exercise, orlistat, low, intermediate and high dose of Mangifera indica were tested for 40 days. The various manipulative options studied to include swimming test (physical exercise), orlistat (200mg/kg), ethanolic extract of Mangifera indica low dose (100mg/kg), ethanolic extract of Mangifera indica intermediate dose (300mg/kg), and ethanolic extract of Mangifera indica high dose (900 mg/kg). The parameters were evaluated including body weight on alternate days for 40 days. Biochemical parameters such as HDL, LDL, Triglycerides and total cholesterol were measured using diagnostic kits. Blood glucose level was measured. On 41st days animals were sacrificed and their organ weights (heart, liver, spleen and kidney), and fat pad weights (epididymal and mesenteric fat pads) were measured. There was a significant reduction in body weight, Triglycerides, total cholesterol, LDL, Blood glucose levels, organ and fat pad weights and increase in HDL level of the animals treated with Ethanolic extracts of Mangifera indica and exercise. The present study revealed that [HFD + Intermediate dose of ethanolic extract of Mangifera indica (300 mg/kg) + exercise] group showed more potential effects than rest of all treatment groups.