A SIMPLE, ONE-FLASK TRANSFORMATION OF KETONES TO N-METHYL LACTAMS

被引：10
|
作者：
HOFFMAN, RV
SALVADOR, JM
机构：
[1] Department of Chemistry New Mexico State University Las Cruces
来源：
TETRAHEDRON LETTERS | 1991年 / 32卷 / 22期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/S0040-4039(00)74345-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-flask conversion of cyclic ketones to N-methyl lactams is described. Reaction of the ketone with triethylorthoformate generates an acetal which is reacted in situ with N-(((p-nitrobenzene)sulfonyl)oxy methylamine 2a(CH3NH-OSO2C6H4NO2). Dealkylation of the resulting O-ethyl imidate with sodium iodide gives the lactam. A variety of lactams, including macrocyclic lactams, are produced simply and in good yields.
引用
收藏
页码：2429 / 2432
页数：4
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