STABLE TRIPLE HELICES ARE FORMED UPON BINDING OF RNA OLIGONUCLEOTIDES AND THEIR 2'-O-METHYL DERIVATIVES TO DOUBLE-HELICAL DNA

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作者：
ESCUDE, C
SUN, JS
ROUGEE, M
GARESTIER, T
HELENE, C
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来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1992年 / 315卷 / 13期
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Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Pyrimidine oligoribonucleotides bind to the major groove of double-helical DNA at homopurine.homopyrimidine sequences. They recognize Watson-Crick base pairs by forming T. A x U and C. G x C base triplets via Hoogsteen hydrogen bonding. The stability of these triple helices is much higher than that of triple helices formed by oligodeoxyribonucleotides as shown by an increase of the temperature at which half-dissociation of the third strand occurs. When the 2'-hydroxyl group of ribose moieties is replaced by 2'-O-methyl substituent, triple helix stability is further increased.
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页码：521 / 525
页数：5
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