A multi-objective methodology is presented to tailor the characteristics of metal-matrix laminates at elevated temperatures. Fabrication and material parameters are included in the design process. A unique feature is the concurrent inclusion of effects from fabrication, residual stresses, material non-linearity, and thermo-mechanical loading on the properties of the post-fabricated laminate. Unidirectional and cross-ply Gr/Cu composites are tailored for improved axial strength. Similarly, a cross-ply Gr/Cu laminate is tailored for improved stiffness and strength. Strong beneficial coupling was observed between the fabrication process, laminate characteristics, and thermo-mechanical loading.