THE DISCOVERY OF DUP-753, A POTENT, ORALLY ACTIVE NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST

被引:225
|
作者
DUNCIA, JV
CARINI, DJ
CHIU, AT
JOHNSON, AL
PRICE, WA
WONG, PC
WEXLER, RR
TIMMERMANS, PBMWM
机构
[1] DuPont Merck Pharmaceutical Company, Wilmington, Delaware, 19880-0402, Experimental Station
关键词
D O I
10.1002/med.2610120203
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:149 / 191
页数:43
相关论文
共 50 条
  • [31] EFFECTS OF THE NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST, DUP753, ON TUBULOGLOMERULAR FEEDBACK RESPONSES AND RENAL-FUNCTION
    BRAAM, B
    MITCHELL, KD
    NAVAR, LG
    HYPERTENSION, 1992, 19 (01) : I133 - I133
  • [32] PREVENTION OF COLD-INDUCED HYPERTENSION IN RATS BY LOSARTAN (DUP 753), A NONPEPTIDE ANGIOTENSIN-II (ANGII) RECEPTOR ANTAGONIST
    VANBERGEN, P
    FREGLY, MJ
    ROSSI, F
    FASEB JOURNAL, 1992, 6 (05): : A1829 - A1829
  • [33] COMPARISON OF INHIBITORY POTENCY BY NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS PD123177 AND DUP-753 ON PROXIMAL NEPHRON AND RENAL TRANSPORT
    COGAN, MG
    LIU, FY
    WONG, PC
    TIMMERMANS, PBMWM
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1991, 259 (02): : 687 - 691
  • [34] NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS .11. PHARMACOLOGY OF EXP3174 - AN ACTIVE METABOLITE OF DUP753, AN ORALLY ACTIVE ANTIHYPERTENSIVE AGENT
    WONG, PC
    PRICE, WA
    CHIU, AT
    DUNCIA, JV
    CARINI, DJ
    WEXLER, RR
    JOHNSON, AL
    TIMMERMANS, PBMWM
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1990, 255 (01): : 211 - 217
  • [35] CARDIAC HEMODYNAMIC-EFFECTS OF THE NONPEPTIDE, ANGIOTENSIN II-RECEPTOR ANTAGONIST, DUP-753, IN CONSCIOUS LONG EVANS AND BRATTLEBORO RATS
    BATIN, P
    GARDINER, SM
    COMPTON, AM
    KEMP, PA
    BENNETT, T
    BRITISH JOURNAL OF PHARMACOLOGY, 1991, 103 (02) : 1585 - 1591
  • [36] INHIBITION OF TRANSPORT IN THE EARLY PROXIMAL CONVOLUTED TUBULE (PCT) BY THE NONPEPTIDE ANGIOTENSIN-II ANTAGONIST DUP 753
    COGAN, MG
    XIE, MH
    LIU, FY
    CLINICAL RESEARCH, 1990, 38 (02): : A314 - A314
  • [37] PHARMACOLOGICAL PROFILE OF VALSARTAN - A POTENT, ORALLY-ACTIVE, NONPEPTIDE ANTAGONIST OF THE ANGIOTENSIN-II AT1-RECEPTOR SUBTYPE
    CRISCIONE, L
    DEGASPARO, M
    BUHLMAYER, P
    WHITEBREAD, S
    RAMJOUE, HPR
    WOOD, J
    BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (02) : 761 - 771
  • [38] INTESTINAL TRANSPORT AND RENAL EXCRETION OF URATE IS ALTERED BY A SPECIFIC ANGIOTENSIN-II (AII) ANTAGONIST, DUP-753
    HATCH, M
    FREEL, RW
    VAZIRI, ND
    FASEB JOURNAL, 1995, 9 (03): : A368 - A368
  • [39] NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - STUDIES WITH EXP9270 AND DUP753
    WONG, PC
    PRICE, WA
    CHIU, AT
    CARINI, DJ
    DUNCIA, JV
    JOHNSON, AL
    WEXLER, RR
    TIMMERMANS, BMWM
    HYPERTENSION, 1990, 15 (06) : 823 - 834
  • [40] THE EFFECT OF DUP753, A NONPEPTIDE ANGIOTENSIN-II ANTAGONIST, ON ARTERIES AND ARTERIOLES IN RENAL HYPERTENSIVE RATS
    WANG, DH
    KEELAN, CA
    PREWITT, RL
    FASEB JOURNAL, 1991, 5 (06): : A1752 - A1752