A CONVENIENT SYNTHESIS OF 5-SUBSTITUTED-2,3-DIHYDROTHIOPHENES

被引：0

作者：

ONEIL, IA ^{[1
]}

HAMILTON, KM ^{[1
]}

MILLER, JA ^{[1
]}

YOUNG, RJ ^{[1
]}

机构：

[1] WELLCOME RES LABS,DEPT MED CHEM,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

SYNLETT | 1995年 / 02期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of gamma-thiobutyrolactone with KHMDS and N-(5-chloro-2-pyridyl)triflimide (Comin's reagent) gives the corresponding thiolenoltriflate in good yield. Coupling of the thiolenortriflate with Gilman cuprates proceeds smoothly to give the 5-substituted-2,3-dihydrothiophenes. The synthesis of a homochiral thiolactone is described. Conversion to the corresponding thiolenoltriflate proceeds in good yield using the conditions described above. The coupling with Gilman cuprates gives homochiral 5-substituted-2,3-dihydrothiophenes in good yield.

引用

页码：151 / 152

页数：2

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