A CONVENIENT SYNTHESIS OF 5-SUBSTITUTED-2,3-DIHYDROTHIOPHENES

被引：0
|
作者：
ONEIL, IA [1 ]
HAMILTON, KM [1 ]
MILLER, JA [1 ]
YOUNG, RJ [1 ]
机构：
[1] WELLCOME RES LABS,DEPT MED CHEM,BECKENHAM BR3 3BS,KENT,ENGLAND
来源：
SYNLETT | 1995年 / 02期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of gamma-thiobutyrolactone with KHMDS and N-(5-chloro-2-pyridyl)triflimide (Comin's reagent) gives the corresponding thiolenoltriflate in good yield. Coupling of the thiolenortriflate with Gilman cuprates proceeds smoothly to give the 5-substituted-2,3-dihydrothiophenes. The synthesis of a homochiral thiolactone is described. Conversion to the corresponding thiolenoltriflate proceeds in good yield using the conditions described above. The coupling with Gilman cuprates gives homochiral 5-substituted-2,3-dihydrothiophenes in good yield.
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页码：151 / 152
页数：2
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