EXPRESSION OF MEMORY TO THE TERMINAL DIFFERENTIATION INDUCING ACTIVITY OF TIAZOFURIN IN HL-60 LEUKEMIA-CELLS

被引:4
|
作者
SOKOLOSKI, JA
SARTORELLI, AC
机构
[1] YALE UNIV,SCH MED,CTR COMPREHENS CANC,DEPT PHARMACOL,333 CEDAR ST,POB 3333,NEW HAVEN,CT 06510
[2] YALE UNIV,SCH MED,CTR COMPREHENS CANC,DEV & THERAPEUT PROGRAM,NEW HAVEN,CT 06510
关键词
HL-60; LEUKEMIA; DIFFERENTIATION; IMP DEHYDROGENASE; TIAZOFURIN;
D O I
10.1016/0145-2126(91)90016-M
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tiazofurin, a potent inhibitor of inosine 5'-phosphate dehydrogenase, depletes guanine nucleotide pools and induces granulocytic maturation of HL-60 leukemia cells. These effects are reversed when cells exposed to this agent for 24 h are washed and placed in tiazofurin-free medium. HL-60 cells treated with tiazofurin for a 24 h period, retain a precommitment memory that lessens the time interval necessary for cells to express the mature phenotype upon re-exposure. That protein synthesis was required for maintaining the expression of memory was demonstrated by the finding that memory was blocked when primed cells were exposed to cycloheximide during the intervening inducer-free interval, but not during the priming or subsequent drug exposure periods. The findings have significance with respect to the sequence of events required for commitment to a differentiation pathway.
引用
收藏
页码:395 / 402
页数:8
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