A METHOD FOR THE SYNTHESIS OF RACEMIC AND OPTICALLY-ACTIVE 2-SUBSTITUTED 9-(2',3'-DIHYDROXYPROPYL)-8-AZAHYPOXANTHINES AND 8-AZAADENINES

被引：12

作者：

BARILI, PL ^{[1
]}

BIAGI, G ^{[1
]}

GIORGI, I ^{[1
]}

LIVI, O ^{[1
]}

SCARTONI, V ^{[1
]}

机构：

[1] UNIV PISA,IST CHIM FARMACEUT & TOSSICOL,I-56100 PISA,ITALY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 05期

关键词：

D O I：

10.1002/jhet.5570280529

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several 9-(2',3'-O-isopropylidene)- and 9-(2',3'-dihydroxypropyl)-8-azahypoxanthines and 8-azaadenines were synthesized by a "one pot" method starting from the acetonide of racemic or (S)-l-azido-2,3-dihydroxypropane, obtained from D-mannitol. 9-(2',3'-Dihydroxypropyl)-8-azapurines were tested as adenosine deaminase inhibitors.

引用

页码：1351 / 1355

页数：5

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