Ethonalic leaf extract of Andrographis paniculata-induced oxidative stress in the testis and epididymis of Male Wistar Rats

被引：0

作者：

Narayana, Satya K. ^{[1
]}

Naidu, Kumaraswamy C. ^{[1
]}

Trinath, D. ^{[1
]}

Reddy, Sreenivasula P. ^{[1
]}

Reddy, Srinivasulu M. ^{[1
]}

Suneetha, Y. ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Zool, Tirupati 517502, Andhra Pradesh, India

来源：

MEDICAL SCIENCE | 2014年 / 14-15卷 / 54-62期

关键词：

Andrographis paniculata; lipid peroxidation; Super oxide dismutase; Catalase;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Andrographis paniculata has been used as a traditional medicine and a predominant constituent in 26 Ayurvedic formulations over the last two decades. Its impact on the male fertility is a controversial from the past few years. In the present study we have investigated the antioxidant enzyme status and the indices of lipid peroxidation in the testis and epididymis of male wistar rats. Male wistar rats were exposed to 20, 200 and 1000mg/kg body weight of ethanolic extract of Andrographis paniculata (high dose) orally for 65 days daily. Control rats received normal saline only. Tissues were washed, homogenized and the levels of super oxide dismutatse, catalase and lipid peroxidation was determined. Results showed an increase in the levels of lipid peroxidation and decrease in the levels of super oxide dismutase and catalase in the testis and epididymis.

引用

页码：7 / 13

页数：7

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