QUANTITATIVE ASSESSMENT OF SYNAPTIC DENSITY IN THE ENTORHINAL CORTEX IN ALZHEIMERS-DISEASE

被引:68
|
作者
SCHEFF, SW
SPARKS, L
PRICE, DA
机构
[1] Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky
关键词
D O I
10.1002/ana.410340309
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We quantified the synaptic density in the entorhinal cortex (Brodmann area 28) in autopsy material from 10 individuals with Alzheimer's disease and compared them to 11 age-matched, postmortem-matched control subjects without dementia, using standard electron microscopy. The statistical data showed no change in synaptic density between control and Alzheimer subjects, in either lamina III or V of the cortex. There were no correlations between synaptic density and synaptic apposition length or density of senile plaques. The entorhinal cortex stands in marked contrast to other cortical areas that show a significant decline in synaptic numbers with Alzheimer's disease. This preservation of synaptic numbers may be related to a plasticity response that is greater in the entorhinal area than in other areas of the cortex.
引用
收藏
页码:356 / 361
页数:6
相关论文
共 50 条
  • [41] ALTERNATIVE SPLICING OF THE BETA-A4 AMYLOID GENE OF ALZHEIMERS-DISEASE IN CORTEX OF CONTROL AND ALZHEIMERS-DISEASE PATIENTS
    KONIG, G
    SALBAUM, JM
    WIESTLER, O
    LANG, W
    SCHMITT, HP
    MASTERS, CL
    BEYREUTHER, K
    MOLECULAR BRAIN RESEARCH, 1991, 9 (03): : 259 - 262
  • [42] AMPA-SELECTIVE GLUTAMATE-RECEPTOR SUBTYPE IMMUNOREACTIVITY IN THE ENTORHINAL CORTEX OF NONDEMENTED ELDERLY AND PATIENTS WITH ALZHEIMERS-DISEASE
    ARMSTRONG, DM
    IKONOMOVIC, MD
    SHEFFIELD, R
    WENTHOLD, RJ
    BRAIN RESEARCH, 1994, 639 (02) : 207 - 216
  • [43] ASTROCYTIC REACTION IN CEREBRAL-CORTEX IN ALZHEIMERS-DISEASE
    BALKO, G
    OLEJNICZAK, PW
    MANDYBUR, TI
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1989, 48 (03): : 337 - 337
  • [44] VOLUME DENSITY OF SENILE PLAQUES IN ALZHEIMERS-DISEASE
    VERANO, A
    CHANDRAN, R
    FARALDI, F
    BENNET, D
    REYES, MG
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1990, 49 (03): : 307 - 307
  • [45] Synaptic plasticity in entorhinal cortex
    Jung, MW
    Yun, SH
    Cheong, MY
    COGNITION AND EMOTION IN THE BRAIN, 2003, 1250 : 147 - 159
  • [46] GLYCOGEN ACCUMULATIONS IN THE CEREBRAL-CORTEX IN ALZHEIMERS-DISEASE
    MANN, DMA
    SUMPTER, PQ
    DAVIES, CA
    YATES, PO
    ACTA NEUROPATHOLOGICA, 1987, 73 (02) : 181 - 184
  • [47] NEUROPATHOLOGICAL CHANGES IN THE VISUAL-CORTEX IN ALZHEIMERS-DISEASE
    ARMSTRONG, RA
    NOCKLIN, D
    SUMI, SM
    ALVORD, EC
    NEUROSCIENCE RESEARCH COMMUNICATIONS, 1990, 6 (03) : 163 - 171
  • [48] A STEREOLOGICAL ANALYSIS OF THE CEREBRAL-CORTEX IN ALZHEIMERS-DISEASE
    SUMPTER, PQ
    DAVIES, CA
    MANN, DMA
    YATES, PO
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1985, 11 (01) : 76 - 77
  • [49] SYNAPTIC PLASTICITY VS PATHOLOGY IN ALZHEIMERS-DISEASE - IMPLICATIONS FOR TRANSPLANTATION
    COTMAN, CW
    NEURONAL GRAFTING AND ALZHEIMERS DISEASE, 1989, : 54 - 62
  • [50] STRUCTURAL DYNAMICS OF SYNAPTIC JUNCTIONAL AREAS IN AGING AND ALZHEIMERS-DISEASE
    BERTONIFREDDARI, C
    FATTORETTI, P
    CASOLI, T
    GAMBINI, M
    MEIERRUGE, W
    ULRICH, J
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 673 : 285 - 292