STRUCTURE OF FK506 - A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM STREPTOMYCES

被引：542
|
作者：
TANAKA, H [1 ]
KURODA, A [1 ]
MARUSAWA, H [1 ]
HATANAKA, H [1 ]
KINO, T [1 ]
GOTO, T [1 ]
HASHIMOTO, M [1 ]
TAGA, T [1 ]
机构：
[1] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 606,JAPAN
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1987年 / 109卷 / 16期
关键词：
D O I：
10.1021/ja00250a050
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：5031 / 5033
页数：3
相关论文
共 50 条
  • [31] POTENTIATION OF PROGESTERONE RECEPTOR-MEDIATED TRANSCRIPTION BY THE IMMUNOSUPPRESSANT FK506
    TAI, PKK
    ALBERS, MW
    MCDONNELL, DP
    CHANG, H
    SCHREIBER, SL
    FABER, LE
    BIOCHEMISTRY, 1994, 33 (35) : 10666 - 10671
  • [32] TAUTOMERIC PHENOMENON OF A NOVEL POTENT IMMUNOSUPPRESSANT (FK506) IN SOLUTION .1. ISOLATION AND STRUCTURE DETERMINATION OF TAUTOMERIC COMPOUNDS
    NAMIKI, Y
    KIHARA, N
    KODA, S
    HANE, K
    YASUDA, T
    JOURNAL OF ANTIBIOTICS, 1993, 46 (07): : 1149 - 1155
  • [33] Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil
    Tokime, T
    Nozaki, K
    Kikuchi, H
    NEUROSCIENCE LETTERS, 1996, 206 (2-3) : 81 - 84
  • [34] Changes of Bone Metabolism in Immunosuppressant, FK506 Treated Rats.
    Wakabayashi, H.
    Kanda, J.
    Katayanagi, E.
    Takahashi, A.
    Onodera, K.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 : S339 - S339
  • [35] DEGRADATION AND MANIPULATIONS OF THE IMMUNOSUPPRESSANT FK506 - PREPARATION OF POTENTIAL SYNTHETIC INTERMEDIATES
    COLEMAN, RS
    DANISHEFSKY, SJ
    HETEROCYCLES, 1989, 28 (01) : 157 - 161
  • [36] EFFECTS OF THE IMMUNOSUPPRESSANT FK506 ON A PENETRATING KERATOPLASTY REJECTION MODEL IN THE RAT
    NISHI, M
    HERBORT, CP
    MATSUBARA, M
    MORISHITA, Y
    NISHIMURA, M
    NIEDA, M
    MORI, S
    MOCHIZUKI, M
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1993, 34 (08) : 2477 - 2486
  • [37] Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis
    Marko Blažič
    Gregor Kosec
    Špela Baebler
    Kristina Gruden
    Hrvoje Petković
    Microbial Cell Factories, 14
  • [38] Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis
    Blazic, Marko
    Kosec, Gregor
    Baebler, Spela
    Gruden, Kristina
    Petkovic, Hrvoje
    MICROBIAL CELL FACTORIES, 2015, 14
  • [39] Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506
    Prakash, Ajit
    Rajan, Sreekanth
    Yoon, Ho Sup
    PROTEIN SCIENCE, 2016, 25 (04) : 905 - 910
  • [40] INHIBITION OF FKBP ROTAMASE ACTIVITY BY IMMUNOSUPPRESSANT FK506 - TWISTED AMIDE SURROGATE
    ROSEN, MK
    STANDAERT, RF
    GALAT, A
    NAKATSUKA, M
    SCHREIBER, SL
    SCIENCE, 1990, 248 (4957) : 863 - 866
12345