MOLECULAR-CLONING AND CHROMOSOMAL LOCALIZATION TO 17Q21 OF THE HUMAN WNT3-GENE

被引：23

作者：

ROELINK, H

WANG, J

BLACK, DM

SOLOMON, E

NUSSE, R

机构：

[1] STANFORD UNIV,BECKMAN CTR,DEPT DEV BIOL,HOWARD HUGHES MED INST,STANFORD,CA 94305

[2] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

来源：

GENOMICS | 1993年 / 17卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1412

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In mouse mammary tumors, the Wnt-3 gene can be activated by proviral insertion. Here we report on the isolation of a human homolog, WNT3. A genomic clone was isolated by use of mouse Wnt-3 sequences as a probe, after which cDNA containing most of the protein-encoding domain of the human gene was obtained by PCR. Comparison between the deduced mouse and human WNT-3 protein sequences showed four changes in 333 amino acids. WNT3 is located on chromosome 17q21. The gene was not found to be amplified or rearranged in a collection of human breast tumors. © 1993 Academic Press, Inc.

引用

页码：790 / 792

页数：3

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