PULMONARY VASODILATOR DRUGS DECREASE LUNG LIQUID PRODUCTION IN FETAL SHEEP

被引:12
|
作者
CUMMINGS, JJ [1 ]
机构
[1] SUNY Buffalo, DEPT PEDIAT, BUFFALO, NY 14222 USA
关键词
PULMONARY CIRCULATION; BIRTH TRANSITION; FETUS;
D O I
10.1152/jappl.1995.79.4.1212
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
To examine a potential relationship between pulmonary vasodilatation and fetal lung liquid production, I measured lung liquid production in 20 fetal sheep at 130 +/- 4 days gestation while using several agents known to increase pulmonary blood flow. Thirty-two studies were done in which left pulmonary arterial flow (Qlpa) was measured by an ultrasonic Doppler flow probe and net lung luminal liquid production (J(v)) was measured by plotting the change in lung luminal liquid concentration of radiolabeled albumin, an impermeant tracer that was mixed into the lung liquid at the start of each study. Qlpa and J(v) were measured during a 1- to 2-h baseline period and then during a 1- to 2-h infusion period in which the fetuses received either an intravenous infusion of acetylcholine (n = 8), prostaglandin D-2 (n = 10), or the leukotriene blocker FPL-55712 (n = 7). These vasodilators work by different mechanisms, each mechanism having been implicated in the decrease in pulmonary vascular resistance seen at birth. Control (saline) infusions (n = 7) caused no change in either Qlpa or J(v) over 4 h. All vasodilator agents significantly increased pulmonary blood flow and decreased J(v). Pulmonary arterial pressure did not change significantly in either the control, acetylcholine, prostaglandin, or leukotriene-blocker studies, indicating that pulmonary vascular resistance decreased. Thus agents that increase pulmonary blood flow by mechanisms that occur at birth also decrease lung liquid production in fetal lambs.
引用
收藏
页码:1212 / 1218
页数:7
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