PRODUCTION OF TGF-BETA AND HGF RECEPTOR BY A DIFFERENTIATED PAPILLARY THYROID-CARCINOMA CELL-LINE (B-CPAP) - IMPLICATION IN MALIGNANCY

被引：0
|
作者：
PAULIN, C
AVALLET, O
TARDY, F
SAEZ, J
FUSCO, A
FABIEN, N
机构：
[1] HOP DEBROUSSE,INRA,INSERM,U307,F-69332 LYON,FRANCE
[2] LYON SUD MED SCH,CNRS,INSERM,U189,F-69921 OULLINS,FRANCE
[3] UNIV REGGIO CALABRIA,FAC MED & CHIRURG CATANZARO,DIPARTIMENTO MED SPERIMENTALE & CLIN,I-88100 CATANZARO,ITALY
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1995年 / 7卷 / 03期
关键词：
THYROID CANCER; TGF-BETA; C-MET; P53;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The B-CPAP cell line was obtained from a human differentiated papillary thyroid carcinoma. Previous studies showed that the cells present thyroid characteristics such as thyroglobulin production, phenotypic alterations such as synthesis of human chorionic gonadotropin hormone (HCG), expression of neuron specific enolase (NSE) and protein S100, and also somatic mutations of p53 and K-rns oncogenes. The present data further characterize this cell line and show an overexpression of transforming growth factor (TGF beta 1) and c-met gene product i.e. the receptor for human growth factor (HGF). The relation between the phenotypic and somatic alterations in the process of malignancy are discussed.
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页码：657 / 660
页数：4
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