SYNTHESIS OF THE TRIFLUOROACETATE SALT OF ASPARTIC-ACID BETA-SEMIALDEHYDE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF L-LYSINE, L-THREONINE, AND L-METHIONINE

被引：0

作者：

TUDOR, DW

LEWIS, T

ROBINS, DJ

机构：

[1] UNIV GLASGOW,DEPT CHEM,GLASGOW G12 8QQ,SCOTLAND

[2] ICI AGROCHEM ZENECA LTD,JEALOTTS HILL RES STN,BRACKNELL RG12 6EY,BERKS,ENGLAND

来源：

SYNTHESIS-STUTTGART | 1993年 / 11期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The trifluoroacetate salt of aspartic acid beta-semialdehyde, an important intermediate in the biosynthesis Of L-lysine, L-threonine, and L-methionine has been prepared in DL-, L-, and D-forms as stable solid hydrates 13 in 43 % overall yield by ozonolysis of doubly protected allylglycine, followed by careful deprotection with trifluoroacetic acid.

引用

页码：1061 / 1062

页数：2

共 36 条

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[35] An escape from Italy, the discovery of S-adenosylmethionine, and the biosynthesis of creatine by Giulio L.!Cantoni -: S-adenosylmethionine;: a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate -: (!Cantoni, G. L. (1953) J-Biol. Chem. 204, 403-416) -: Enzymatic mechanism of creatine synthesis (!Cantoni, G. L., and !Vignos, P. J., Jr. (1954) J-Biol. Chem. 209, 647-659) -: art. no. e35
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[36] BIOSYNTHESIS OF THE UNUSUAL AMINO-ACID (4R)-4-[(E)-2-BUTENYL]-4-METHYL-L-THREONINE OF CYCLOSPORINE-A - IDENTIFICATION OF 3(R)-HYDROXY-4(R)-METHYL-6(E)-OCTENOIC ACID AS A KEY INTERMEDIATE BY ENZYMATIC IN-VITRO SYNTHESIS AND BY IN-VIVO LABELING TECHNIQUES
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