SYNTHESIS OF THIAZOLE AND SELENAZOLE DERIVATIVES WITH AFFINITY FOR THE ODORANT-BINDING PROTEIN

被引：7
|
作者：
NAPOLITANO, E
PELOSI, P
机构：
[1] UNIV PISA,IST IND AGR,VIA S MICHELE 4,I-56124 PISA,ITALY
[2] UNIV PISA,DIPARTIMENTO CHIM BIOORGAN,I-56100 PISA,ITALY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(00)80439-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new ligands for odorant-binding proteins (OBPs) have been prepared, to be used in protein structure studies: the photoaffinity label 2-azido-4-butyl-5-propylthiazole, the NMR probe 2-trifluoromethyl-4-butyl-5-propylthiazole and the X-ray probe 2-amino-4-butyl-5-propylselenazole. All three compounds bind the bovine OBP with dissociation constants in the micromolar range.
引用
收藏
页码：1603 / 1606
页数：4
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