SYNTHESIS, REACTIONS, AND C-13 FT NMR-SPECTROSCOPY OF POLYMER-BOUND STEROIDS

Dehydrocholic acid (3,7,12-trioxo-β-cholanoic acid) and cholic acid (3α,7α,12α-trihydroxy-5β-cholanoic acid) were attached, via their carboxyl groups, to chloromethylated poly(styrene-2% divinylbenzene) to form the polymers 1 and 6, respectively. Synthetic transformations of the bound steroids containing the carbonyl and hydroxyl groups and esterification of hydroxyl functions was obtained by 13C NMR spectra of solvent swollen polymer gels. The 13C NMR spectra of the bound steroids represents a major advance in the analysis of polymer-supported species, permitting structural assignments to be made, on a qualitative basis, of the intact polymer without resorting to cleavage reactions of the bound material. © 1990, American Chemical Society. All rights reserved.