mRNA vaccine delivery using lipid nanoparticles

被引：451

作者：

Reichmuth, Andreas M. ^{[1
,2
]}

Oberli, Matthias A. ^{[1
,2
]}

Jaklenec, Ana ^{[2
]}

Langer, Robert ^{[1
,2
,3
,4
,5
]}

Blankschtein, Daniel ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] MIT, Inst Med Engn & Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[4] MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Harvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol, Boston, MA USA

来源：

THERAPEUTIC DELIVERY | 2016年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

adjuvant; cancer immunotherapy; cationic lipid; drug delivery; lipid nanoparticle; mRNA; oligonucleotide; therapeutic vaccine; vaccine;

D O I：

10.4155/tde-2016-0006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells. mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy applications, but also have great potential as prophylactic vaccines. Efficient delivery of mRNA vaccines will be key for their success and translation to the clinic. Among potential nonviral vectors, lipid nanoparticles are particularly promising. Indeed, lipid nanoparticles can be synthesized with relative ease in a scalable manner, protect the mRNA against degradation, facilitate endosomal escape, can be targeted to the desired cell type by surface decoration with ligands, and as needed, can be codelivered with adjuvants.

引用

页码：319 / 334

页数：16

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