PHASE-II STUDY OF CHLOROZOTOCIN IN LEUKEMIA AND OTHER HEMATOLOGIC MALIGNANCIES

被引：0
|
作者：
PAVLOVSKY, S
WOOLLEY, PV
GARAY, G
SCAGLIONE, C
HOTH, D
SCHEIN, PS
机构：
[1] GEORGETOWN UNIV, MED CTR, DEPT MED, WASHINGTON, DC 20007 USA
[2] GEORGETOWN UNIV, MED CTR, DIV MED ONCOL, WASHINGTON, DC 20007 USA
[3] GEORGETOWN UNIV, MED CTR, VINCENT T LOMBARDI CANC RES CTR, WASHINGTON, DC 20007 USA
[4] ACAD NACL MED, INST INVEST HEMATOL, BUENOS AIRES, ARGENTINA
来源：
CANCER TREATMENT REPORTS | 1981年 / 65卷 / 11-1期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chlorozotocin is a glucose-containing chloroethylnitrosourea that is relatively nonmyelosuppressive at doses that produce significant antileukemic activity in L1210 murine leukemia. The present phase II trial tested chlorozotocin using the nonmyelosuppressive 120-mg/m2 dose in leukemia and lymphoma patients. This dose was given weekly or daily for 3 days to the leukemia patients and every 6 wk to the lymphoma patients. Chlorozotocin was not effective in heavily pretreated leukemia and lymphoma patients but gave evidence of activity, particularly in Hodgkin''s disease, that might be exploited in a less heavily treated population.
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页码：1109 / 1111
页数：3
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