METABOLIC BASIS FOR DIFFERENTIAL GLUTAMINE REQUIREMENTS OF HUMAN LEUKEMIA-CELL LINES

被引：33

作者：

KITOH, T ^{[1
]}

KUBOTA, M ^{[1
]}

TAKIMOTO, T ^{[1
]}

HASHIMOTO, H ^{[1
]}

SHIMIZU, T ^{[1
]}

SANO, H ^{[1
]}

AKIYAMA, Y ^{[1
]}

MIKAWA, H ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT PEDIAT,KYOTO 606,JAPAN

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 1990年 / 143卷 / 01期

关键词：

D O I：

10.1002/jcp.1041430120

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We compared the ability of human leukemia cell lines of various origins to grow in glutamine‐deficient media. The growth of B lymphoblastoid cell lines, including promyelocytic HL‐60, is highly dependent on glutamine, whereas T‐cell lines are able to proliferate in glutamine‐free media. Such glutamine dependency has a good inverse correlation with the activity of glutamine synthetase. Moreover, glutamine synthetase can be induced in glutamine‐deficient media, especially in glutamine‐independent cells. In HL‐60 cells, glutamine deprivation results in the decrease of both ATP and dATP levels. The addition of adenine to the culture medium abolishes these changes without restoring cell growth, indicating that the effects of glutamine deprivation on cell growth cannot be fully explained by the perturbation of adenine nucleotide pools. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：150 / 153

页数：4

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