CARBOPLATIN TREATMENT INDUCES DOSE-DEPENDENT INCREASES IN THE FREQUENCY OF MICRONUCLEI IN EHRLICH ASCITES TUMOR-CELLS

被引：9
|
作者：
QUINTANA, E
PERTUSA, J
GONZALEZ, R
RENAUPIQUERAS, J
机构：
[1] HOSP LA FE,CTR INVEST,E-46009 VALENCIA,SPAIN
[2] UNIV VALENCIA,FAC CIENCIAS BIOL,DEPT ANIM BIOL,E-46100 VALENCIA,SPAIN
来源：
MUTATION RESEARCH | 1994年 / 322卷 / 01期
关键词：
CARBOPLATIN; CIS-DIAMMINE(1,1-CYCLOBUTANEDICARBOXYLATO)-PLATINUM(II); MICRONUCLEI; EHRLICH ASCITES TUMOR;
D O I：
10.1016/0165-1218(94)90032-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The effect of various doses (75-300 mg/kg b.w.) of carboplatin on the induction of micronuclei in Ehrlich ascites tumor (EAT) cells was studied. Carboplatin treatment resulted in a dose-dependent increase in the frequency of micronucleated EAT cells. Carboplatin treatment also decreased the mitotic index. The dose-effect curves were linear-quadratic for all the parameters studied. The maximal effect of the drug was obtained in all the treatments after 48 h.
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页码：55 / 60
页数：6
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