THE EFFECT OF AMINOGUANIDINE ON THE BLOOD-RETINAL BARRIER IN STREPTOZOCIN-INDUCED DIABETIC RATS

被引：0
|
作者：
CHO, HK
KOZU, H
PEYMAN, GA
PARRY, GJ
KHOOBEHI, B
机构：
[1] LOUISIANA STATE UNIV,MED CTR,SCH MED,CTR EYE,NEW ORLEANS,LA 70112
[2] LOUISIANA STATE UNIV,MED CTR,SCH MED,DEPT NEUROL,NEW ORLEANS,LA 70112
来源：
OPHTHALMIC SURGERY AND LASERS | 1991年 / 22卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The effect of aminoguanidine hydrochloride (AG) on the blood-retinal barrier was studied in rats with streptozocin-induced diabetes. Half of the rats were given AG (100 mg/kg/day) while the remainder received no treatment. Vitreous fluorophotometry was performed on all rats before STZ injection and 2 weeks after induction of diabetes mellitus. Two weeks after STZ injection the mean 60-minute vitreous fluorescein concentration following dye injection had increased more in the nontreated group than in the AG-treated group, suggesting that AG may have some beneficial effect on the breakdown of the blood-retinal barrier.
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页码：44 / 47
页数：4
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