Activators of peroxisome proliferator activated receptor (PPAR) regulate fatty acid metabolism and can induce adipocyte differentiation. We show here that the gamma subtype of PPAR is expressed at high levels in adipose tissue in contrast to a variety of other tissues, where little gene expression was noted. In addition, PPAR gamma is present at low levels in 3T3-L1 preadipocytes and is induced dramatically during adipocyte conversion using either normal differentiating conditions (fetal calf serum, dexamethasone, isobutylmethylxanthine, and insulin) or the PPAR activator, WY-14,643. Thus PPAR gamma may be important for adipose cell development and function.
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Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USAIowa State Univ, Dept Anim Sci, Ames, IA 50011 USA
Long, Mary J.
Sairam, M. Ram
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Inst Rech Clin Montreal, Mol Reprod Res Lab, Montreal, PQ H2W 1R7, CanadaIowa State Univ, Dept Anim Sci, Ames, IA 50011 USA
Sairam, M. Ram
Komar, Carolyn M.
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Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA
W Virginia Sch Osteopath Med, Dept Biomed Sci, Lewisburg, WV 24901 USAIowa State Univ, Dept Anim Sci, Ames, IA 50011 USA