PURIFICATION OF TRYPANOSOMA-CRUZI SURFACE-PROTEINS INVOLVED IN ADHESION TO HOST-CELLS

被引：22
|
作者：
VILLALTA, F [1 ]
LIMA, MF [1 ]
ZHOU, L [1 ]
机构：
[1] MEHARRY MED COLL,DEPT MICROBIOL,NASHVILLE,TN 37208
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)90764-E
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have identified four surface 83 kDa proteins of pI values 6.3, 6.4, 6.5 and 6.6 in T. cruzi trypomastigotes which specifically bind to rat heart myoblasts. These proteins were purified by isoelectric focusing and anion-exchange chromatography in an FPLC system. These 83 kDa proteins inhibit the attachment of trypomastigotes to myoblasts in a concentration-dependent manner, indicating that these trypomastigote proteins mediate the attachment of trypomastigotes to heart myoblasts. © 1990.
引用
收藏
页码：925 / 931
页数：7
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