BCL-2 GENE REARRANGEMENTS IN FOLLICULAR LYMPHOMAS

被引：4
|
作者：
CRISAN, D
ANSTETT, MJ
机构：
来源：
LABORATORY MEDICINE | 1993年 / 24卷 / 09期
关键词：
D O I：
10.1093/labmed/24.9.579
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The t(14;18) chromosome translocation is the cytogenetic hallmark of follicular lymphomas. The study of this translocation at the molecular level has led to the discovery of a new oncogene, bcl-2. This gene is the first member of a new class of oncogenes: the regulators of programmed cell death. It is activated by the translocation-induced gene rearrangement, and the malignant cells become virtually immortal. Detection of bcl-2 gene rearrangements is important not only for diagnosis, but also for monitoring patients with follicular lymphomas throughout the course of their disease.
引用
收藏
页码：579 / 588
页数：10
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