THYMIDYLATE SYNTHETASE - TARGET ENZYME IN CANCER CHEMOTHERAPY

被引：581
作者：
DANENBERG, PV
机构：
[1] UNIV SO CALIF, CTR COMPREHENS CANC, LOS ANGELES, CA 90024 USA
[2] UNIV S CALIF, SCH MED, DEPT BIOCHEM, LOS ANGELES, CA 90031 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1977年 / 473卷 / 02期
关键词：
D O I：
10.1016/0304-419X(77)90001-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：73 / 92
页数：20
相关论文
共 89 条
[81]   INHIBITION OF THYMIDYLATE SYNTHETASE BY 5-FORMYL-2'-DEOXYURIDYLATE AND 5-HYDROXYMETHYL-2'-DEOXYURIDYLATE [J].
SANTI, DV ;
SAKAI, TT .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1971, 42 (05) :813-&
[82]   IRREVERSIBLE INHIBITION OF THYMIDYLATE SYNTHETASE BY 5-FORMYL-2'-DEOXYURIDYLIC ACID [J].
SANTI, DV ;
SAKAI, TT .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 46 (03) :1320-&
[83]   MODEL STUDIES OF THYMIDYLATE SYNTHETASE . NEIGHBORING-GROUP FACILITATION OF ELECTROPHILIC SUBSTITUTION REACTIONS OF URACIL FURANOSIDES [J].
SANTI, DV ;
BREWER, CF .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1968, 90 (22) :6236-&
[84]   NUCLEOPHILIC SUBSTITITION REACTIONS OF 5-ACETOXYMETHYL-AND 5 PARA NITROPHENOXYMETHYLURACILS [J].
SANTI, DV ;
POGOLOTT.AL .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1971, 8 (02) :265-&
[85]   MECHANISM OF INTERACTION OF THYMIDYLATE SYNTHETASE WITH 5-FLUORODEOXYURIDYLATE [J].
SANTI, DV ;
MCHENRY, CS ;
SOMMER, H .
BIOCHEMISTRY, 1974, 13 (03) :471-481
[86]  
SHARMA RK, 1973, FED PROC, V32, P591
[87]  
SLAVIK K, 1967, MOL PHARMACOL, V3, P370
[88]   PURIFICATION AND AMINO-ACID ANALYSIS OF AN ACTIVE-SITE PEPTIDE FROM THYMIDYLATE SYNTHETASE CONTAINING COVALENTLY BOUND 5-FLUORO-2'-DEOXYURIDYLATE AND METHYLENETETRAHYDROFOLATE [J].
SOMMER, H ;
SANTI, DV .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 57 (03) :689-695
[89]   EFFECT OF AMINES ON BISULFITE-CATALYZED HYDROGEN ISOTOPE-EXCHANGE AT 5 POSITION OF URIDINE [J].
WATAYA, Y ;
HAYATSU, H .
BIOCHEMISTRY, 1972, 11 (19) :3583-&
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