PHOSPHATIDYLSERINE IN THE OUTER LEAFLET OF RED-BLOOD-CELLS FROM BETA-THALASSEMIA PATIENTS MAY EXPLAIN THE CHRONIC HYPERCOAGULABLE STATE AND THROMBOTIC EPISODES

被引：1
|
作者：
BORENSTAINBENYASHAR, V
BARENHOLZ, Y
HYAM, E
RACHMILEWITZ, EA
ELDOR, A
机构：
[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MEMBRANE BIOCHEM,IL-91010 JERUSALEM,ISRAEL
[2] HADASSAH UNIV HOSP,DEPT HEMATOL,IL-91120 JERUSALEM,ISRAEL
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 1993年 / 44卷 / 01期
关键词：
RED BLOOD CELLS; MEMBRANE ASYMMETRY; PROTHROMBINASE ASSAY; BETA-THALASSEMIA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Investigation of red blood cells from beta-thalassemia patients by means of prothrombinase assay reveals phosphatidylserine in the outer leaflet of the plasma membrane. This might explain their elevated susceptibility to phagocytosis by macrophages and the chronic hypercoagulable state, frequent thrombotic events, and life-long platelet activation that are found in thalassemic patients. (C) 1993 Wiley-Liss, Inc.
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页码：63 / 65
页数：3
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