STRUCTURE ELUCIDATION OF RESTRICTICIN, A NOVEL ANTIFUNGAL AGENT FROM PENICILLIUM-RESTRICTUM

被引：31
|
作者：
HENSENS, OD
WICHMANN, CF
LIESCH, JM
VANMIDDLESWORTH, FL
WILSON, KE
SCHWARTZ, RE
机构：
来源：
TETRAHEDRON | 1991年 / 47卷 / 24期
关键词：
D O I：
10.1016/S0040-4020(01)86432-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The structures and absolute stereochemistry of restriction (1), its N,N-dimethyl derivative (4) and desglycyl hydrolysis product (3), isolated from Penicillium restrictum, have been determined on the basis of spectroscopic evidence. They belong to a new class of broad spectrum antifungal agents representing substituted tetrahydropyanyl ethers incorporating triene and glycyl ester side chains.
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页码：3915 / 3924
页数：10
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