ACUTE LYMPHOBLASTIC-LEUKEMIA ASSOCIATED WITH A T(1 19)(Q23 P13) IN AN ADULT

被引：5
|
作者：
OHNO, H
INOUE, T
AKASAKA, T
OKUMURA, A
MIYANISHI, S
OHASHI, I
KIKUCHI, M
MASUYA, M
AMANO, H
IMANAKA, T
OHNO, Y
机构：
[1] Division of Hematology, Tenri Hospital, Tenri
[2] Department of Clinical Pathology, Tenri Hospital and Tenri Medical Institute, Tenri
来源：
INTERNAL MEDICINE | 1993年 / 32卷 / 07期
关键词：
IMMUNOGLOBULIN GENE REARRANGEMENT; E2A PBX1 FUSION GENE; POLYMERASE CHAIN REACTION;
D O I：
10.2169/internalmedicine.32.584
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A cytogenetic study of a 38-year-old patient with acute lymphoblastic leukemia (ALL) revealed a t(1;19)(q23;p13), which is a characteristic translocation of childhood ALL. The leukemic cells were positive for the CD10, CD19, HLA-DR, TdT and cytoplasmic mu-chain. Both of the immunoglobulin heavy chain gene loci were rearranged and the RNA-based polymerase chain reaction demonstrated the E2A/PBX1 fusion transcript which is the result of the t(1;19). This finding suggests that the t(1;19) is implicated not only in childhood ALL but also in adult ALL patients.
引用
收藏
页码：584 / 587
页数：4
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