SYNTHESIS AND BIOLOGICAL-ACTIVITY OF INTERCALATOR SUBSTITUTED BILE STEROIDS

被引：4
|
作者：
BROWN, CL
HARDING, MM
KALMAN, JR
MARJO, CE
RAINONE, S
WEBSTER, LK
机构：
[1] UNIV SYDNEY,DEPT ORGAN CHEM,SYDNEY,NSW 2006,AUSTRALIA
[2] UNIV TECHNOL SYDNEY,DEPT CHEM,SYDNEY,NSW 2007,AUSTRALIA
[3] PETER MACCALLUM CANC INST,EXPTL CHEMOTHERAPY & PHARMACOL,MELBOURNE,VIC 3000,AUSTRALIA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(01)80340-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cholic acid has been functionalised at the 3 and 24 positions with quinoline and quinoxaline chromophores. The 24-quinoline monoester shows significant activity against L1210 mouse leukaemia cells compared to the 3,24-disubstituted quinoline and quinoxaline esters.
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页码：1253 / 1256
页数：4
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