BENZOIC-ACID INHIBITORS OF INFLUENZA-VIRUS NEURAMINIDASE

被引：15
|
作者：
LUO, M
JEDRZEJAS, MJ
SINGH, S
WHITE, CL
BROUILLETTE, WJ
AIR, GM
LAVER, WG
机构：
[1] UNIV ALABAMA,DEPT CHEM,BIRMINGHAM,AL 35294
[2] UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294
[3] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,CANBERRA,ACT 2601,AUSTRALIA
来源：
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | 1995年 / 51卷
关键词：
D O I：
10.1107/S0907444994011698
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A strategy was developed to design non-carbohydrate inhibitors of influenza virus neuraminidase. Using an iterative cycle of modeling, synthesis, biological testing and X-ray crystallography structure determination, a series of inhibitors based on benzoic acid were produced. The refined structures of three compounds complexed with neuraminidase are reported. The results demonstrate the success of this structure-based drug-design strategy.
引用
收藏
页码：504 / 510
页数：7
相关论文
共 50 条
  • [21] Novel α- and β-amino acid inhibitors of influenza virus neuraminidase
    Kati, WM
    Montgomery, D
    Maring, C
    Stoll, VS
    Giranda, V
    Chen, XQ
    Laver, WG
    Kohlbrenner, W
    Norbeck, DW
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (09) : 2563 - 2570
  • [22] MICROMETHOD FOR DETERMINATION OF INFLUENZA-VIRUS NEURAMINIDASE AND ANTI-NEURAMINIDASE
    TAKATSY, G
    BARB, K
    ACTA MICROBIOLOGICA ACADEMIAE SCIENTIARUM HUNGARICAE, 1977, 24 (01): : 72 - 72
  • [23] Influenza virus neuraminidase inhibitors
    Gubareva, LV
    Kaiser, L
    Hayden, FG
    LANCET, 2000, 355 (9206): : 827 - 835
  • [24] EFFECT OF PHYSICOCHEMICAL FACTORS ON INFLUENZA-VIRUS NEURAMINIDASE
    NEKLYUDOVA, LI
    ORLOVA, NG
    MAKAROVA, GI
    VOPROSY VIRUSOLOGII, 1973, (03) : 338 - 341
  • [25] THE ACTIVE-SITE OF INFLUENZA-VIRUS NEURAMINIDASE
    GHATE, A
    AIR, G
    PROTEIN ENGINEERING, 1995, 8 : 60 - 60
  • [26] DETERMINATION OF ANTIBODY AGAINST INFLUENZA-VIRUS NEURAMINIDASE
    PROFETA, ML
    BERGAMINI, F
    ZANETTI, A
    GIORNALE DI MICROBIOLOGIA, 1971, 19 : 63 - 83
  • [27] PURIFICATION OF NEURAMINIDASE FROM INFLUENZA-VIRUS ON IMMUNOSORBENT
    YAKUBOV, LA
    SAVICH, IM
    BEKLEMISHEV, AB
    BIOCHEMISTRY-MOSCOW, 1984, 49 (10) : 1353 - 1358
  • [28] INTERFERON INDUCTION BY INFLUENZA-VIRUS - SIGNIFICANCE OF NEURAMINIDASE
    CHOMIK, M
    ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 1981, 29 (01) : 109 - 114
  • [29] CHANGES IN THE NEURAMINIDASE OF NEUROVIRULENT INFLUENZA-VIRUS STRAINS
    WARD, AC
    VIRUS GENES, 1995, 10 (03) : 253 - 260
  • [30] DETERMINATION OF INFLUENZA-VIRUS NEURAMINIDASE INHIBITION TITERS
    RICHMAN, DD
    MURPHY, BR
    CLINE, WL
    ALLING, DW
    BULLETIN OF THE WORLD HEALTH ORGANIZATION, 1975, 52 (02): : 233 - 234
12345