HEPATITIS-C VIRUS DOES NOT CAUSE NONALCOHOLIC STEATOHEPATITIS

被引：18
|
作者：
ROGERS, DW
LEE, CH
POUND, DC
KUMAR, S
CUMMINGS, OW
LUMENG, L
机构：
[1] INDIANA UNIV,SCH MED,DEPT MED,975 W WALNUT ST,IB 424,INDIANAPOLIS,IN 46202
[2] INDIANA UNIV,SCH MED,DEPT PATHOL,INDIANAPOLIS,IN 46202
[3] RICHARD L ROUDEBUSH VET ADM MED CTR,INDIANAPOLIS,IN 46202
来源：
DIGESTIVE DISEASES AND SCIENCES | 1992年 / 37卷 / 11期
关键词：
NONALCOHOLIC STEATOHEPATITIS; HEPATITIS-C VIRUS; POLYMERASE CHAIN REACTION; ANTI-C100-3; EIA;
D O I：
10.1007/BF01299852
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The pathogenesis of nonalcoholic steatohepatitis (NASH) remains poorly understood. Since inflammation and fatty changes are associated with hepatitis C (HCV) infection, we have tested the role of HCV in the genesis of NASH. Five consecutive cases of classic NASH were tested by Abbott anti-c100-3 EIA and polymerase chain reaction (PCR) to detect HCV-RNA. All serum specimens were negative for anti-c100-3 (or anti-HCV EIA) and HCV PCR. Based on this study, we conclude that HCV does not play a causative or contributing role in the pathogenesis of NASH.
引用
收藏
页码：1644 / 1647
页数：4
相关论文
共 50 条
  • [21] GENOTYPING OF HEPATITIS-C VIRUS, DOES IT HAVE CLINICAL RELEVANCE
    BOGOMOLSKIYAHALOM, V
    ASHUR, Y
    KLEIN, A
    TURKASPA, R
    HEPATOLOGY, 1994, 20 (04) : A333 - A333
  • [22] Fibrosis heterogeneity in nonalcoholic steatohepatitis and Hepatitis C virus needle core biopsy specimens
    Goldstein, NS
    Hastah, F
    Galan, MV
    Gordon, SC
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2005, 123 (03) : 382 - 387
  • [23] IGM ANTIBODY TO HEPATITIS-C VIRUS IN ACUTE AND CHRONIC HEPATITIS-C
    QUIROGA, JA
    CAMPILLO, ML
    CATILLO, I
    BARTOLOME, J
    PORRES, JC
    CARRENO, V
    HEPATOLOGY, 1991, 14 (01) : 38 - 43
  • [24] GENOTYPES OF HEPATITIS-C VIRUS IN ITALIAN PATIENTS WITH CHRONIC HEPATITIS-C
    TISMINETZKY, SG
    GEROTTO, M
    PONTISSO, P
    CHEMELLO, L
    RUVOLETTO, MG
    BARALLE, F
    ALBERTI, A
    INTERNATIONAL HEPATOLOGY COMMUNICATIONS, 1994, 2 (02): : 105 - 112
  • [25] HEPATITIS-C VIREMIA IN PATIENTS WITH HEPATITIS-C VIRUS-INFECTION
    LOK, ASF
    CHEUNG, R
    CHAN, R
    LIU, V
    HEPATOLOGY, 1992, 15 (06) : 1007 - 1012
  • [26] CHRONIC HEPATITIS-C - HISTOLOGICAL ACTIVITY AND REPLICATION OF HEPATITIS-C VIRUS
    CHU, HW
    DASH, S
    GERBER, MA
    LABORATORY INVESTIGATION, 1993, 68 (01) : A108 - A108
  • [27] REPLICATIVE LEVEL OF HEPATITIS-C VIRUS (HCV) IN CHRONIC HEPATITIS-C
    HAYASHI, N
    KAMADA, T
    INTERNAL MEDICINE, 1993, 32 (12) : 944 - 945
  • [28] PREVALENCE OF HEPATITIS-C VIRUS IN FAMILY MEMBERS OF PATIENTS WITH HEPATITIS-C
    OSHITA, M
    HAYASHI, N
    KASAHARA, A
    YUKI, N
    TAKEHARA, T
    HAGIWARA, H
    HAYAKAWA, Y
    YASUMATSUYA, Y
    KISHIDA, Y
    FUSAMOTO, H
    KAMADA, T
    JOURNAL OF MEDICAL VIROLOGY, 1993, 41 (03) : 251 - 255
  • [29] THE NEW HEPATITIS-VIRUS - HEPATITIS-C VIRUS
    MACKAY, IR
    MEDICAL JOURNAL OF AUSTRALIA, 1990, 153 (05) : 247 - 249
  • [30] DISCOVERY OF THE HEPATITIS-C VIRUS
    TREPO, C
    COUROUCE, AM
    NOEL, L
    PRESSE MEDICALE, 1990, 19 (34): : 1582 - 1586
12345