DEVELOPMENT OF AN INVITRO MICROTEST TO ASSESS DRUG SUSCEPTIBILITY OF BABESIA-BOVIS AND BABESIA-BIGEMINA

被引：14
|
作者：
BROCKELMAN, CR
TANARIYA, P
机构：
来源：
JOURNAL OF PARASITOLOGY | 1991年 / 77卷 / 06期
关键词：
D O I：
10.2307/3282755
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Continuous cultivation of the bovine hemoparasites Babesia bovis and Babesia bigemina was developed as an in vitro microtest to assess parasite susceptibility to babesicidal compounds. Reproducibility of parasite multiplication rates was independent of culture size, making it possible to use a microscale of 100-mu-l for each test sample. Inhibitory concentrations (IC50s) of a commonly used babesicide, quinuronium sulfate, evaluated by this in vitro method were found to be 5 x 10(-8) g/ml for B. bovis and 2 x 10(-9) g/ml for B. bigemina.
引用
收藏
页码：994 / 997
页数：4
相关论文
共 50 条
  • [41] REGRESSION OF MOUSE SARCOMA M(52)B TREATED WITH BOVINE FASCIA LATA EXTRACT FROM ANIMALS PREVIOUSLY INOCULATED WITH BABESIA-BOVIS AND BABESIA-BIGEMINA
    KING, AC
    SOUTH AFRICAN MEDICAL JOURNAL, 1980, 58 (05): : 191 - 193
  • [42] BABESIA-RODHAINI, BABESIA-BOVIS, AND BABESIA-BIGEMINA - ANALYSIS AND SORTING OF RED-CELLS FROM INFECTED-MOUSE OR CALF BLOOD BY FLOW FLUORIMETRY USING 33258 HOECHST
    HOWARD, RJ
    RODWELL, BJ
    EXPERIMENTAL PARASITOLOGY, 1979, 48 (03) : 421 - 431
  • [43] Serosurvey of Babesia bovis and Babesia bigemina in cattle in Mongolia
    Battsetseg, Badgar
    Sivakumar, Thillaiampalam
    Naranbaatar, Khandsuren
    Narantsatsral, Sandagdorj
    Myagmarsuren, Punsantsogvoo
    Enkhtaivan, Batsaikhan
    Davaasuren, Batdorj
    Mizushima, Daiki
    Weerasooriya, Gayani
    Igarashi, Ikuo
    Battur, Banzragch
    Yokoyama, Naoaki
    VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS, 2018, 13 : 85 - 91
  • [44] BOVINE BABESIA-BIGEMINA SEROREACTORS IN JAMAICA
    MCGINNIS, B
    GRANT, G
    HUGHJONES, M
    WAGNER, G
    TROPICAL ANIMAL HEALTH AND PRODUCTION, 1989, 21 (04) : 227 - 228
  • [45] FLUORESCENT-ANTIBODY TESTS FOR BABESIA-BIGEMINA AND BABESIA-BERBERA
    GOLDMAN, M
    ROSENBERG, AS
    PIPANO, E
    RESEARCH IN VETERINARY SCIENCE, 1972, 13 (01) : 77 - +
  • [46] THE USE OF TICK TRANSMISSION BY BOOPHILUS-MICROPLUS TO ISOLATE PURE STRAINS OF BABESIA-BOVIS, BABESIA-BIGEMINA AND ANAPLASMA-MARGINALE FROM CATTLE WITH MIXED INFECTIONS
    DALGLIESH, RJ
    STEWART, NP
    VETERINARY PARASITOLOGY, 1983, 13 (04) : 317 - 323
  • [47] OCCURRENCE OF BABESIA-BOVIS (=BABESIA-ARGENTINA) IN A BUFFALO
    SHASTRI, UV
    KURUNDKAR, VD
    INDIAN VETERINARY JOURNAL, 1981, 58 (01): : 61 - 63
  • [48] PRENATAL BABESIA-BIGEMINA INFECTION IN A CALF
    ATWELL, RB
    AUSTRALIAN VETERINARY JOURNAL, 1975, 51 (11) : 539 - 539
  • [49] THE TOXICITY OF ANTIFOLATES IN BABESIA-BOVIS
    NOTT, SE
    BAGNARA, AS
    INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1993, 23 (03) : 399 - 402
  • [50] CHEMOPROPHYLAXIS (IMIDOCARB) AGAINST BABESIA-BIGEMINA AND BABESIA-ARGENTINA INFECTIONS
    TODOROVIC, RA
    VIZCAINO, OG
    GONZALEZ, EF
    ADAMS, LG
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 1973, 34 (09) : 1153 - 1161
12345