SYNTHESIS OF NEW BENZIMIDAZOLE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS

被引：4
|
作者：
BADAWEY, ESAM [1 ]
HASSAN, AMM [1 ]
KAPPE, T [1 ]
机构：
[1] GRAZ UNIV,INST ORGAN CHEM,ORGAN SYNTH ABT,A-8010 GRAZ,AUSTRIA
来源：
ARCHIV DER PHARMAZIE | 1991年 / 324卷 / 06期
关键词：
D O I：
10.1002/ardp.19913240607
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Barbiturates 3 as possible antimicrobial agents were obtained by reacting the N,N'-disubstituted urea 1a or the thiourea analogues 1b,c with the magic malonates 2a,b. On the other hand, reaction of 1a with ethoxycarbonyl isocyanate (4) yielded the substituted s-triazine-2,4,6(1H,3H,5H)-trione 5. The reaction of 4 with 2-aminomethyl-benzimidazole (6) gave the allophanate 7 which upon treatment with Na2CO3 yielded N-(1H-benzimidazol-2-yl)urea 8.
引用
收藏
页码：355 / 357
页数：3
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